Otto Octavius (Earth-21997)

Otto Gunther Octavius was once the CEO of Octavius Industries before it was assimilated by the Ikeru Corporation in a hostile takeover. Suffering from a physical degenerative disorder, Otto sought to use his intelligence to help those who suffered like him, resulting in the creation of a harness that would help those who were physically disabled. He showed off the prototype of such a design at the With Arms Open Wide Expo, an event attended by a young Peter Parker whom he would face off against years later when he transforms into "Doctor Octopus". He is a founding member of the Sinister Six.

After falling victim to his condition, Otto's crimes would continue post-death when the AI of his harness took over control of his wasting body.